FolioStart free

Medicine · Literature

Research papers on Personalized medicine and genomics

Recent and highly-cited academic work on personalized medicine and genomics, gathered from Semantic Scholar, CrossRef and OpenAlex.

Search all 200M+ papers on this topic, free →Or track new personalized medicine and genomics papers automatically as they publish

  1. Precision and Personalized Medicine: How Genomic Approach Improves the Management of Cardiovascular and Neurodegenerative Disease

    Oriana Strianese, Francesca Maria Rizzo, Michele Ciccarelli, et al. · 2020 · Genes · 246 citations

    Life expectancy has gradually grown over the last century. This has deeply affected healthcare costs, since the growth of an aging population is correlated to the increasing burden of chronic diseases. This represents the interesting challenge of how to manage patients with chronic diseases in order to improve health care budgets. Effective primary prevention could represent a promising route. To this end, precision, together with personalized medicine, are useful instruments in order to investigate pathological processes before the appearance of clinical symptoms and to guide physicians to choose a targeted therapy to manage the patient. Cardiovascular and neurodegenerative diseases represe

    Save this paper

  2. From “Personalized” to “Precision” Medicine: The Ethical and Social Implications of Rhetorical Reform in Genomic Medicine

    Eric T. Juengst, Michelle L. McGowan, Jennifer R. Fishman, et al. · 2016 · The Hastings Center Report · 209 citations

    Since the late 1980s, the human genetics and genomics research community has been promising to usher in a "new paradigm for health care"-one that uses molecular profiling to identify human genetic variants implicated in multifactorial health risks. After the completion of the Human Genome Project in 2003, a wide range of stakeholders became committed to this "paradigm shift," creating a confluence of investment, advocacy, and enthusiasm that bears all the marks of a "scientific/intellectual social movement" within biomedicine. Proponents of this movement usually offer four ways in which their approach to medical diagnosis and health care improves upon current practices, arguing that it is mo

    Save this paper

  3. Genomic Medicine, Precision Medicine, Personalized Medicine: What’s in a Name?

    Dan M. Roden, Rachel Fynvola Tyndale · 2013 · Clinical Pharmacology & Therapeutics · 72 citations

    This issue of Clinical Pharmacology & Therapeutics is devoted to genomic medicine, and a reader may reasonably ask what we mean when we use those words. In the initial issue of the journal Genomics in 1987, McKusick and Ruddle pointed out that the descriptor "genome" had been coined in 1920 as a hybrid of "gene" and "chromosome," and that their new journal would focus on the "newly-developing discipline of mapping/sequencing (including analysis of the information)." A key milestone in the field was the generation of the first draft of a human genome in 2000, but this success really represents only one of many milestones in the journey from Mendel to MiSeq.

    Save this paper

  8. BMC3PM: bioinformatics multidrug combination protocol for personalized precision medicine and its application in cancer treatment

    Majid Mokhtari, Samane Khoshbakht, Mohammad Esmaeil Akbari, et al. · 2023 · BMC Medical Genomics · 7 citations

    Background: In recent years, drug screening has been one of the most significant challenges in the field of personalized medicine, particularly in cancer treatment. However, several new platforms have been introduced to address this issue, providing reliable solutions for personalized drug validation and safety testing. In this study, we developed a personalized drug combination protocol as the primary input to such platforms. Methods: To achieve this, we utilized data from whole-genome expression profiles of 6173 breast cancer patients, 312 healthy individuals, and 691 drugs. Our approach involved developing an individual pattern of perturbed gene expression (IPPGE) for each patient, which

    Save this paper

  11. Advances in Personalized Medicine: Integrating Genomics and Precision Therapeutics

    Xiaoyu Qian, Jia Liao, Yu Fang · 2024 · Medicine insights. · 1 citations

    Personalized medicine represents a transformative approach to healthcare by tailoring medical treatments to individual patients based on their genetic, environmental, and lifestyle factors. This review explores the integration of genomics and precision therapeutics in personalized medicine, highlighting technological advances, applications, challenges, and future directions. Key findings include the significant impact of high-throughput sequencing, bioinformatics, artificial intelligence, and targeted therapies in improving patient outcomes. Despite existing challenges, the future of personalized medicine looks promising, with emerging technologies paving the way for more effective and indiv

    Save this paper

  13. ADVANCEMENTS IN PRECISION MEDICINE: FROM GENOMICS TO PERSONALIZED CARE

    Mehwish Abbas · 2021 · International journal of applied biology and forensic

    Precision medicine, an innovative approach to disease prevention and treatment, leverages individual variability in genes, environment, and lifestyle. The integration of genomic sequencing, biomarker profiling, and bioinformatics into routine clinical practice is transforming how diseases are diagnosed and treated. This article explores the evolution of precision medicine from its genomic foundation to real-time personalized therapeutic strategies. It evaluates the progress in Pakistan’s research and healthcare infrastructure while identifying existing challenges, such as data standardization, affordability, and clinician education. Moreover, it highlights global advancements in oncology, ph

    Save this paper

  15. The Role of Genomics in Precision Medicine and Personalized Treatment in Diabetes Mellitus

    Fatma Hilal Yagin, Badicu Georgian · 2024 · Journal of Exercise Science & Physical Activity Reviews

    Diabetes mellitus, a chronic metabolic disorder marked by persistent hyperglycemia, represents a significant global health challenge. The disease manifests in various forms, including Type 1 diabetes (T1D), Type 2 diabetes (T2D), gestational diabetes, and rare monogenic types, each with distinct etiologies. Advances in omics technologies, particularly genomics, have provided significant advances in the understanding of diabetes by providing insight into its genetic and molecular basis. This study delves into the role of genomics in diabetes research, highlighting how genome-wide association studies (GWAS) have uncovered numerous genetic loci associated with T1D and T2D. The findings elucidat

    Save this paper

  16. Personalized Medicine using Genomics and Artificial Intelligence: Transforming Healthcare in the Era of Precision Medicine

    Mukesh Kumari, Preveen Kumari · 2026 · International Journal of Innovative Science and Research Technology (IJISRT)

    Personalized medicine, also known as precision medicine, represents a paradigm shift in healthcare by tailoring diagnosis, prevention, and treatment strategies to an individual’s genetic, environmental, and lifestyle factors. The integration of genomics and artificial intelligence (AI) has accelerated this transformation by enabling high-throughput data analysis, predictive modelling, and targeted therapeutic interventions. This paper explores the convergence of genomics and AI, highlighting technological advancements, applications in disease management, challenges, and future prospects. Recent studies indicate that AI-driven genomic analysis can improve diagnostic accuracy by over 20–30% an

    Save this paper

  19. Construction of personalized genomics model and clinical application in precision medicine

    Haoyu Li · 2024 · Applied Mathematics and Nonlinear Sciences

    Sequencing technology continues to evolve, and pharmacogenomics is increasingly pivotal in the pursuit of personalized medicine. This study delineates the personalized genomics model into two core modules for framework construction: data preprocessing and prediction. Within the data preprocessing module, a denoising submodule and a genomic feature distribution alignment module are dedicated to processing the genomic features associated with diseases and assimilating them into the spatial feature distribution of the model. The prediction module employs a fully connected neural network alongside a graph convolutional neural network to forecast drug dosages based on the disease's genomic featur

    Save this paper

  20. AI-Enabled Personalized Medicine: Integrating Genomics, Clinical Decision Support & Precision Therapeutics

    Muneendra Madam, Hareesh Divadari · 2026 · The Bioscan

    Personalized medicine aims to provide healthcare based on the biological and clinicalcharacteristics of individual patients. Advancement in genomics has made it possible to identifygenetic modifications related to disease risk, drug response, and treatment outcomes, but interpretinglarge and complex datasets remains challenging. Artificial intelligence (AI) is useful in analyzinggenomic, clinical, and treatment-related information and connecting these data with clinicaldecisions. This review examines the role of AI in personalized medicine, with a focus on genomicanalysis, clinical decision support, and precision therapeutics. AI applications in genomic medicineinclude variant interpretation

    Save this paper

Write your paper with these sources

Folio is the integrity-first research workspace: search 200M+ papers, save sources, and write with citations that format themselves. Free for students and researchers.

Start writing free →