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Research papers on Long COVID

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  1. Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms

    Amy D. Proal, Michael B. VanElzakker · 2021 · Frontiers in Microbiology · 833 citations

    The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic of coronavirus disease 2019 (COVID-19). Across the globe, a subset of patients who sustain an acute SARS-CoV-2 infection are developing a wide range of persistent symptoms that do not resolve over the course of many months. These patients are being given the diagnosis Long COVID or Post-acute sequelae of COVID-19 (PASC). It is likely that individual patients with a PASC diagnosis have different underlying biological factors driving their symptoms, none of which are mutually exclusive. This paper details mechanisms by which RNA viruses beyond just SARS-CoV-2 have be connected to long-term health

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  2. A Scoping Review on Long COVID-19: Physiological and Psychological Symptoms Post-Acute, Long-Post and Persistent Post COVID-19

    Krishna Mohan Surapaneni, Manmohan Singhal, Sofia Rani Saggu, et al. · 2022 · Healthcare · 15 citations

    Background: The identification of persistent symptoms of chronic/long COVID-19 is crucial in understanding the management of long haulers of post COVID-19. Methods: Pub Med (Medline) database was scoped for original articles based on a search strategy related to the objectives. The selected articles post-screening were analyzed for variables relating to chronic/long COVID-19. Results were analyzed using descriptive statistics. Results: A total of 33 studies were reviewed. A total of 60% of the studies were observational studies and most of them were from high income countries. Almost half of the studies were in phase 3 of post-COVID-19, i.e., symptoms lasting >24 weeks. Among the physiolo

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  3. Potential of Black Seeds (Nigella sativa) in the Management of Long COVID or Post-acute Sequelae of COVID-19 (PASC) and Persistent COVID-19 Symptoms – An Insight

    Naina Mohamed Pakkir Maideen, Abdurazak Hassan Jumale, Ibrahim Ramadan Barakat, et al. · 2023 · Infectious Disorders - Drug Targets · 7 citations

    Background: Some individuals may experience symptoms persisting for many months after the recovery from COVID-19 and patients with Long COVID are managed mainly with symptomatic treatment and supportive care. Objective: This review article focuses on the beneficial effects of black seeds (Nigella Sativa) in the management of long COVID and persistent COVID symptoms. Methods: The literature was searched in databases such as LitCOVID, Web of Science, Google Scholar, bioRxiv, medRxiv, Science Direct, EBSCO, Scopus, Embase, and reference lists to identify studies, which evaluated various effects of black seeds (N. sativa) related to signs and symptoms of Long COVID. Results: Black seeds (

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  7. Post-Acute-COVID-19-Illness Neuropsychiatric Sequelae

    Attapon Cheepsattayakorn · 2021 · Open Access Journal of Pulmonary & Respiratory Sciences

    Direct viral invasion, neurodegeneration, microvascular thrombosis, neuroinflammation, and severe systemic inflammation can be the causes of post-acute-COVID-19- illness neuropathology [1-4], supported by brain parenchyma and vessel changes of possibly driven inflammation in neurons, supportive cells, and brain vasculature in COVID-19 autopsy series [5,6]. A role in persistent brain effects of SARSCoV-2 (COVID-19) may be played by an accumulation of memory T cells, a biomarker of immunosenescence in tissue injury and aging, accompanying with the decreased ability to respond to new antigens that are demonstrated in chronic low-level brain inflammation [7].

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  10. Effect of COVID Vaccine on Long COVID: An Observational Study on Hospitalised Patients in North India

    Sandeep Budhiraja, Abhaya Indrayan, Monica Mahajan · 2024 · Effect of COVID Vaccine on Long COVID: An Observational Study on Hospitalised Patients in North India

    We know that vaccination reduces the risk of hospitalisation and death but how these vaccines impact long-COVID is under debate. The current study analyses the patterns of long-COVID amongst vaccinated and unvaccinated hospitalised patients during the three waves in India. From the computerised medical records of COVID patients admitted to a group of hospitals in and around Delhi every 3rd case of wave-1 and wave-2 and all cases of wave-3 were telephonically contacted in April 2022 for symptoms and their duration of long-COVID and their vaccination status. Of the 6676 contacted, 6056 (90.7%) responded. These were compared for two groups: fully vaccinated (913) and unvaccinated at the time o

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  11. Age Differences in Becoming COVID Long-Haulers and in Post-Acute Sequelae of SARS-CoV-2

    Qiao Wu, Eileen Crimmins · 2021 · Innovation in Aging

    Abstract People who have had COVID-19 can suffer from the continuation of Post-Acute Sequelae of SARS-CoV-2 (PASC), also known as “long COVID”, for months after infection. Understanding PASC is important for treatment, care, and projecting future health of the population. Since older adults are at higher risk of severe illness and consequences from COVID, we hypothesize that they are more likely to become COVID long-haulers and report more symptoms at the time of diagnosis and three months after. We use a nationally representative sample of adults from the Understanding America Study COVID-19 Survey, from March to December 2020, to estimate the prevalence of long COVID and ide

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  12. Post-acute COVID-19 gastrointestinal sequelae: Mechanisms of persistent dysbiosis, intestinal barrier dysfunction, and emerging long-COVID phenotypes

    Ahmed Salman · 2026 · World Journal of Clinical Infectious Diseases

    Post-acute coronavirus disease 2019 (COVID-19) syndrome (long COVID) affects 10%-30% of survivors and commonly presents with prolonged gastrointestinal symptoms, including chronic diarrhea, irritable bowel syndrome-like symptoms, and functional dyspepsia that may persist beyond 12 months. Gut dysbiosis-the depletion of short-chain fatty acid (SCFA)-producing commensals, such as Fae calibacterium prausnitzii and the enrichment of proinflammatory taxa, such as Ruminococcus gnavus -has been proposed as a central mechanism alongside intestinal barrier dysfunction, mucosal immune dysregulation, and persistent systemic inflammation. Severe acute respiratory syndrome coronavirus 2 infects intestin

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