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Research papers on Cancer immunotherapy

Recent and highly-cited academic work on cancer immunotherapy, gathered from Semantic Scholar, CrossRef and OpenAlex.

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  1. Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group

    I. Puzanov, A. Diab, K. Abdallah, et al. · 2017 · Journal for Immunotherapy of Cancer · 1,796 citations

    Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse events (irAEs). Many of these are driven by the same immunologic mechanisms responsible for the drugs’ therapeutic effects, namely blockade of inhibitory mechanisms that suppress the immune system and protect body tissues from an unconstrained acute or chronic immune response. Skin, gut, endocrine, lung and musculoskeletal irAEs are relatively common, whereas cardiovascular, hematologic, renal, neurologic and ophthalmologic irAEs occur much less f

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  2. Cancer Immunotherapy Update: FDA-Approved Checkpoint Inhibitors and Companion Diagnostics

    J. Twomey, Baolin Zhang · 2021 · The AAPS Journal · 556 citations

    Immune checkpoint inhibitors (ICIs) are considered a new standard-of-care across many cancer indications. This review provides an update on ICIs approved by the Food and Drug Administration (FDA), with focus on monoclonal antibodies that target the programmed cell death 1 (PD-1) or its ligand, PD-1 ligand 1 (PD-L1), including information on their clinical indications and associated companion diagnostics. The information is further discussed with strategies for identifying predictive biomarkers to guide the clinical use of PD-1/PD-L1-targeted therapies.

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  4. Predictive biomarkers for cancer immunotherapy with immune checkpoint inhibitors

    R. Bai, Zheng Lv, Dong-Sheng Xu, et al. · 2020 · Biomarker Research · 393 citations

    Although the clinical development of immune checkpoint inhibitors (ICIs) therapy has ushered in a new era of anti-tumor therapy, with sustained responses and significant survival advantages observed in multiple tumors, most patients do not benefit. Therefore, more and more attention has been paid to the identification and development of predictive biomarkers for the response of ICIs, and more in-depth and comprehensive understanding has been continuously explored in recent years. Predictive markers of ICIs efficacy have been gradually explored from the expression of intermolecular interactions within tumor cells to the expression of various molecules and cells in tumor microenvironment, and

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  5. Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors.

    E. De Martin, J. Michot, B. Papouin, et al. · 2018 · Journal of hepatology · 390 citations

    BACKGROUND & AIMS Immunotherapy for metastatic cancer can be complicated by the onset of hepatic immune-related adverse events (IRAEs). This study compared hepatic IRAEs associated with anti-programmed cell death protein 1 (PD-1)/PD ligand 1 (PD-L1) and anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) monoclonal antibodies (mAbs). METHODS Among 536 patients treated with anti-PD-1/PD-L1 or CTLA-4 immunotherapies, 19 (3.5%) were referred to the liver unit for grade ≥3 hepatitis. Of these patients, nine had received anti-PD-1/PD-L1 and seven had received anti-CTLA-4 mAbs, in monotherapy or in combination with anti-PD-1. Liver investigations were undertaken in these 16 patients, including viral

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  7. EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors

    M. Kostine, A. Finckh, C. Bingham, et al. · 2020 · Annals of the Rheumatic Diseases · 242 citations

    Background Rheumatic and musculoskeletal immune-related adverse events (irAEs) are observed in about 10% of patients with cancer receiving checkpoint inhibitors (CPIs). Given the recent emergence of these events and the lack of guidance for rheumatologists addressing them, a European League Against Rheumatism task force was convened to harmonise expert opinion regarding their identification and management. Methods First, the group formulated research questions for a systematic literature review. Then, based on literature and using a consensus procedure, 4 overarching principles and 10 points to consider were developed. Results The overarching principles defined the role of rheumatologists in

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  8. Cancer immunotherapy with immune checkpoint inhibitors (ICIs): potential, mechanisms of resistance, and strategies for reinvigorating T cell responsiveness when resistance is acquired

    H. Marei, Anwarul Hasan, G. Pozzoli, et al. · 2023 · Cancer Cell International · 211 citations

    Cancer is still the leading cause of death globally. The approval of the therapeutic use of monoclonal antibodies against immune checkpoint molecules, notably those that target the proteins PD-1 and PD-L1, has changed the landscape of cancer treatment. In particular, first-line PD-1/PD-L1 inhibitor drugs are increasingly common for the treatment of metastatic cancer, significantly prolonging patient survival. Despite the benefits brought by immune checkpoint inhibitors (ICIs)-based therapy, the majority of patients had their diseases worsen following a promising initial response. To increase the effectiveness of ICIs and advance our understanding of the mechanisms causing cancer resistance,

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  9. Immune Checkpoint Inhibitors in 10 Years: Contribution of Basic Research and Clinical Application in Cancer Immunotherapy

    J. B. Lee, H. R. Kim, S. Ha · 2022 · Immune Network · 154 citations

    Targeting immune evasion via immune checkpoint pathways has changed the treatment paradigm in cancer. Since CTLA-4 antibody was first approved in 2011 for treatment of metastatic melanoma, eight immune checkpoint inhibitors (ICIs) centered on PD-1 pathway blockade are approved and currently administered to treat 18 different types of cancers. The first part of the review focuses on the history of CTLA-4 and PD-1 discovery and the preclinical experiments that demonstrated the possibility of anti-CTLA-4 and anti-PD-1 as anti-cancer therapeutics. The approval process of clinical trials and clinical utility of ICIs are described, specifically focusing on non-small cell lung cancer (NSCLC), in wh

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  11. Immunotherapy in triple negative breast cancer: beyond checkpoint inhibitors

    Y. Abdou, A. Goudarzi, Jia Xin Yu, et al. · 2022 · NPJ Breast Cancer · 111 citations

    The development of immunotherapy agents has revolutionized the field of oncology. The only FDA-approved immunotherapeutic approach in breast cancer consists of immune checkpoint inhibitors, yet several novel immune-modulatory strategies are being actively studied and appear promising. Innovative immunotherapeutic strategies are urgently needed in triple negative breast cancer (TNBC), a subtype of breast cancer known for its poor prognosis and its resistance to conventional treatments. TNBC is more primed to respond to immunotherapy given the presence of more tumor infiltrating lymphocytes, higher PD-L1 expression, and higher tumor mutation burden relative to the other breast cancer subtypes,

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  12. Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors

    Elena Catanzaro, Manuel Beltrán-Visiedo, L. Galluzzi, et al. · 2024 · Cellular and Molecular Immunology · 108 citations

    While immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the clinical management of various malignancies, a large fraction of patients are refractory to ICIs employed as standalone therapeutics, necessitating the development of combinatorial treatment strategies. Immunogenic cell death (ICD) inducers have attracted considerable interest as combinatorial partners for ICIs, at least in part owing to their ability to initiate a tumor-targeting adaptive immune response. However, compared with either approach alone, combinatorial regimens involving ICD inducers and ICIs have not always shown superior clinical activity. Here, we discuss accumulating evidence on the therapeut

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  13. Immune-checkpoint inhibitors for the treatment of metastatic melanoma: a model of cancer immunotherapy.

    P. Queirolo, A. Boutros, E. Tanda, et al. · 2019 · Seminars in cancer biology · 97 citations

    Melanoma has always been described as an immunogenic tumor. Despite that, until 2011 the standard of care in metastatic melanoma was chemotherapy, with low response rates and no clear impact on overall survival. Melanoma was the first cancer type to drive the use of immune-checkpoint inhibitors into clinical practice, which revolutionized the therapeutic paradigm not only in melanoma, but also in an increasing number of tumors. In this review, the preclinical bases and the main clinical studies that led to the approval of immune-checkpoint inhibitors in advanced melanoma will be described with insights on novel combinations of treatments and on prognostic and predictive biomarkers.

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  14. Sustained and targeted delivery of checkpoint inhibitors by metal-organic frameworks for cancer immunotherapy

    Shahad K. Alsaiari, S. Qutub, Shichao Sun, et al. · 2021 · Science Advances · 90 citations

    Delivery of antibodies using smart frameworks affords sustained and targeted activation of T cells for improved immunotherapy. The major impediments to the implementation of cancer immunotherapies are the sustained immune effect and the targeted delivery of these therapeutics, as they have life-threatening adverse effects. In this work, biomimetic metal-organic frameworks [zeolitic imidazolate frameworks (ZIFs)] are used for the controlled delivery of nivolumab (NV), a monoclonal antibody checkpoint inhibitor that was U.S. Food and Drug Administration–approved back in 2014. The sustained release behavior of NV-ZIF has shown a higher efficacy than the naked NV to activate T cells in hematolog

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  15. Targeting the Tumor Microenvironment for Improving Therapeutic Effectiveness in Cancer Immunotherapy: Focusing on Immune Checkpoint Inhibitors and Combination Therapies

    I-Tsu Chyuan, C. Chu, P. Hsu · 2021 · Cancers · 62 citations

    Simple Summary Immune checkpoint inhibitors (ICIs) constitute a paradigm shift in cancer therapy, and it has greatly expanded our knowledge of anticancer immunity and has introduced breakthroughs in cancer therapy. However, despite the promising results in the use of immunotherapy in some cancers, numerous patients do not respond to ICIs without the existence of a clear predictive biomarker. This review provides an overview of recent advances in cellular and molecular factors within the tumor microenvironment (TME) to identify possible mechanisms of immunotherapy resistance, as well as to develop novel combination strategies for cancer immunotherapy. The in-depth exploration of complexity wi

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  16. Combination Cancer Immunotherapy of Nanoparticle-Based Immunogenic Cell Death Inducers and Immune Checkpoint Inhibitors

    Jing Qi, Feiyang Jin, Xiaoling Xu, et al. · 2021 · International Journal of Nanomedicine · 56 citations

    Abstract Cancer immunotherapy is a promising treatment strategy that aims to strengthen immune responses against cancer. However, the low immunogenicity of tumor cells and inhibition of effector T cells in the tumor immunosuppressive microenvironment remain two major challenges. Immunogenic cell death (ICD) inducers not only directly kill cancer cells but also increase the tumor immunogenicity and induce antitumor immune responses. Immune checkpoint inhibitors can alleviate the inhibition of immune cells. Significantly, the combination of ICD inducers and immune checkpoint inhibitors elicits a remarkable antitumor effect. Nanoparticles confer the ability to modulate systemic biodistribution

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  17. Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors

    Sama Rezasoltani, A. Yadegar, Hamid Asadzadeh Aghdaei, et al. · 2020 · Cancer Medicine · 56 citations

    The human gastrointestinal (GI) tract harbors gut microbiome, which plays a crucial role in preserving homeostasis at the intestinal host‐microbial interface. Conversely, specific gut microbiota may be altered during various pathological conditions and produce a number of toxic compounds and oncoproteins, in turn, to induce both inflammatory response and carcinogenesis. Recently, promising findings have been documented toward the implementation of certain intestinal microbiome in the next era of cancer biology and cancer immunotherapy. Notably, intestinal microbiota can cooperate with immune checkpoint inhibitors (ICIs) of its host, especially in enhancing the efficacy of programmed death 1

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  19. Cancer Immunotherapy-Immune Checkpoint Inhibitors in Hepatocellular Carcinoma.

    Jing Bai, P. Liang, Qian Li, et al. · 2021 · Recent patents on anti-cancer drug discovery · 24 citations

    Hepatocellular Carcinoma (HCC) is one of the most common malignancies, the incidence and mortality of which are increasing worldwide. Cancer immunotherapy has revolutionized cancer treatment in recent years. In particular, Immune Checkpoint Inhibitors (ICIs) as new therapeutic tools have demonstrated encouraging antitumor activity and manageable tolerability in HCC. Immunologic checkpoint blockade with antibodies targeting Programmed cell Death-1 (PD-1), Programmed cell Death Ligand-1 (PD-L1), and Cytotoxic T Lymphocyte-Associated protein-4 (CTLA-4) strengthens tumor immunity by restoring exhausted T cells. Although the efficacy of combination treatment strategies using ICIs combined with ot

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  20. Immune Checkpoint Inhibitors Therapy in Prostate Cancer: Lessons Learnt

    Chandok M · 2020 · Annals of Immunology & Immunotherapy · 3 citations

    Immune checkpoint inhibitors (ICIs) therapy has rapidly changed the treatment landscape for a number of cancers but resulted in only marginal success in prostate cancer (PCa). In order to bring about durable clinical benefit of immune check point inhibitor therapy in prostate cancer, it is critical to understand the current status of ICIs therapy for PCa and reasons for low/negligible outcomes. This article summarizes the current status of ICIs therapy in PCa and discusses how ICIs therapy can result in the successful treatment of a specific subset of PCa patients. In this article, we review how immunotherapy and different combination therapies are paving their way by incorporating the strat

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  21. Immunotherapy Breakthrough: Immune Checkpoint Inhibitors in Cancer Treatment

    Zewei Yu · 2024 · Highlights in Science, Engineering and Technology · 3 citations

    Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, offering new possibilities for patients with various malignancies. This review examines the molecular mechanisms of immune checkpoints (ICs), particularly the PD-1/PD-L1 and CTLA-4 pathways, and their roles in tumor immune evasion. Major ICIs, including anti-PD-1/PD-L1 and anti-CTLA-4 drugs, are discussed, with emphasis on their effectiveness in treating both solid and hematological cancers. The review also explores combination treatment strategies that aim to improve therapeutic outcomes. Despite considerable progress, challenges such as drug resistance and immune-related adverse events (irAEs) remain. These issues are a

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