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Research papers on Vitamin D deficiency

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  1. Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses

    M. Chien, Chueh-Yi Huang, Jie-Huei Wang, et al. · 2024 · Nutrition & Diabetes · 82 citations

    Background Vitamin D deficiency has been linked with several adverse maternal and fetal outcomes. Objective To summarize systematic reviews and meta-analyses evaluating the effects of vitamin D deficiency and of vitamin D supplementation in pregnancy on maternal and offspring health-related outcomes. Methods Prior to conducting this umbrella review, we registered the protocol in PROSPERO (CRD42022368003). We conducted searches in PubMed, Embase, and Cochrane Library for systematic reviews and meta-analyses on vitamin D in pregnancy, from database inception to October 2, 2023. All outcomes related to vitamin D in pregnancy obtained from the systematic reviews and meta-analyses were extracted.

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  2. Vitamin D Deficiency Leads to Poorer Health Outcomes and Greater Length of Stay After Total Knee Arthroplasty and Supplementation Improves Outcomes

    K. Vivek, R. Kamal, E. Perera, et al. · 2024 · Jbjs Reviews · 20 citations

    Background: Vitamin D deficiency is increasingly identified as a predictor of poorer outcomes in musculoskeletal disease affecting as many as 1 in 4 people. This study aimed to evaluate the effect of vitamin D supplementation on outcomes after primary total knee arthroplasty (TKA). Methods: A targeted search of terms related to vitamin D and TKA outcomes was performed in PubMed, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, American Academy of Orthopaedic Surgeons, and British Orthopaedic Association databases. The results were analyzed using forest plots with I2 heterogeneity statistics and pooled effects with 95% confidence intervals (CIs) and p values. A p < 0.05 was

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  3. The Real-World Impact of Vitamin D Supplementation on Inflammatory Bowel Disease Clinical Outcomes

    J. Sninsky, S. Sansgiry, T. Taylor, et al. · 2025 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 13 citations

    BACKGROUND & AIMS: Vitamin D deficiency is common in inflammatory bowel disease (IBD) and linked to adverse outcomes, yet the therapeutic role of vitamin D supplementation remains uncertain. We evaluated the real-world impact of vitamin D supplementation on corticosteroid use, emergency department visits, and hospitalizations in patients with IBD. METHODS: We conducted a retrospective cohort study of patients with IBD seen in the national Veterans Health Administration system from 2000 to 2023. All patients who had a vitamin D laboratory assay without a vitamin D prescription in the preceding 3 months were included. We used the quasi-experimental design with difference-in-differences analysi

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  4. Adverse health outcomes in vitamin D supplementation trials for depression: a systematic review.

    K. S. van den Berg, R. Marijnissen, R. V. D. van den Brink, et al. · 2021 · Ageing research reviews · 10 citations

    BACKGROUND Vitamin D deficiency is a universal risk factor for adverse health outcomes. Since depression is consistently associated with low vitamin D levels as well as several adverse health outcomes, vitamin D supplementation may be especially relevant for depressed persons. This review examines the potential benefits of vitamin D for (somatic) health outcomes in randomised controlled supplementation trials for depression. METHOD Systematic literature search to assess whether adverse health outcomes, such as frailty, falls, or cognitive functioning, were included in vitamin D supplementation trials for depression, and whether these outcomes were affected by supplementation. The revised C

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  5. Effects of Maternal Vitamin D Supplementation on Childhood Health

    Nanna S Svensson, Tabia Volqvartz, A. L. Vestergaard, et al. · 2025 · Endocrine Reviews · 9 citations

    Abstract Vitamin D deficiency during pregnancy is associated with an increased risk of health issues in the offspring. Accordingly, recent Endocrine Society guidelines strongly support supplementation in pregnancy, also underlining that without consensus on optimal maternal vitamin D levels, routine screening is currently irrelevant. Knowledge of organ-specific effects of vitamin D and its association with maternal vitamin D status may aid in optimizing vitamin D supplementation. This systematic review outlines the proposed next-generation effects of vitamin D supplementation ≥400 IU/d and explores whether such effects are attributed to a specific maternal vitamin D level obtained during pre

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  6. Neurodevelopmental Outcomes in the Offspring of Women with Vitamin D Deficiency and Women Who Received Vitamin D Supplementation During Pregnancy

    A. Varthaliti, Kalliopi Rodolaki, Vasilios Lygizos, et al. · 2025 · Nutrients · 8 citations

    Vitamin D is an essential nutrient, involved in various biological processes including calcium homeostasis, bone health, immune function, and brain development. Vitamin D from the mother crosses the placenta during pregnancy, directly impacting the neurodevelopment of the fetus. Vitamin D insufficiency is a substantial global health problem, influencing almost 47.9% of individuals, with especially high predominance rates among pregnant women. Background/Objectives: Preclinical studies suggest that maternal vitamin D deficiency results in significant alterations in the development of the offspring’s brain. Nonetheless, randomized clinical trials in humans have produced conflicting results on

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  7. Vitamin D Supplementation in Orthopedic Trauma: Influence on Immune Modulation, Fracture Healing, and Infection Outcomes

    Gaurav Jha, Roopkaran Dhanjal, Ameer Hamza · 2025 · Cureus · 7 citations

    Vitamin D deficiency is a common and correctable problem in orthopedic patients, increasingly recognized for its impact on infection risk, delayed fracture healing, and poor surgical outcomes. Beyond its role in maintaining calcium and phosphate balance, vitamin D supports immune and bone health by promoting antimicrobial peptide production, macrophage activity, and osteoblast function, all of which are essential for infection control and bone repair. This review draws on studies in adult orthopedic populations that assessed vitamin D status in relation to surgical site and periprosthetic infections, fracture healing, nonunion, and fracture prevention. Across these studies, deficiency below

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  10. Impact of Vitamin D Supplementation on Cognition in Adults With Mild to Moderate Vitamin D Deficiency: Outcomes From the VitaMIND Randomized Controlled Trial.

    A. Corbett, Rod S. Taylor, D. Llewellyn, et al. · 2025 · Journal of the American Medical Directors Association · 4 citations

    OBJECTIVES Preserved cognitive health with ageing is a public health imperative. Vitamin D deficiency is associated with poor cognition, but it is unclear whether supplementation would provide benefit, particularly in individuals with mild/moderate deficiencies which do not have other clinical risks. The objective of this study was to establish the impact of daily vitamin D supplementation on cognition in older adults with mild to moderate vitamin D deficiency. DESIGN Two-arm, parallel, 24-month randomized controlled trial, with vitamin D supplementation compared with a placebo. SETTING AND PARTICIPANTS This was a remote trial, completed from home involving 620 adults, ≥ 50 years of age,

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  11. Vitamin D Deficiency and Infantile Rickets Worldwide (2000–2025): Epidemiological Patterns, Public Health Gaps and Interventional Insights

    Ashraf T. Soliman, F. Alyafei, Nada Alaaraj, et al. · 2025 · GSC Advanced Research and Reviews · 4 citations

    Background: Vitamin D deficiency and rickets remain persistent public health challenges affecting infants globally, despite the preventable nature of the condition. Etiology is multifactorial—encompassing limited sun exposure, inadequate maternal and infant nutrition, cultural practices, and insufficient national supplementation programs. Disparities in incidence and outcomes continue to emerge across geographic, socioeconomic, and policy environments. Objectives: To examine global trends in the prevalence of vitamin D deficiency and rickets in infants from 2000 to 2025; to compare the clinical-radiological manifestation of rickets versus subclinical vitamin D deficiency; and to evaluate the

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  13. Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference

    Haiying Niu, Huijie He, Zilong Zhao, et al. · 2024 · Technology and Health Care · 4 citations

    BACKGROUND: Asthma is a major public health concern due to its persistent inflammation of the airways. The intricate and widely variable epidemiology of asthma among nations and populations is a result of the interplay between genetic, environmental, and socioeconomic factors. OBJECTIVE: This study aims to investigate whether VitD supplementation can reduce the frequency of exacerbations (including the frequency of exacerbations requiring systemic corticosteroids and the frequency of exacerbations necessitating trips to the hospital or emergency room, or both) and improve pulmonary function (clinical indicators such as the FEV1% predicted value). METHODS: Computers were used to search Pubmed

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  14. Impact of Vitamin D deficiency on pregnancy outcomes: can we manage it effectively?

    Zlatko Kirovakov, E. Petkova · 2025 · Journal of Biomedical and Clinical Research · 3 citations

    Background: Vitamin D is essential for maternal health, fetal development, and pregnancy outcomes. Despite its importance, vitamin D deficiency is highly prevalent among pregnant women, increasing the risk of gestational diabetes mellitus (GDM), preeclampsia, preterm birth, and fetal growth restriction. Objective: This article explores the impact of maternal vitamin D deficiency on pregnancy outcomes and evaluates current strategies for its management and prevention, and supplementation. Methods: We onducted a comprehensive literature review of clinical trials, meta-analyses, and systematic reviews, focusing on the association between vitamin D levels and pregnancy complications and the ef

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  15. Vitamin D deficiency and pregnancy outcomes: LC-MS/MS-based evaluation in Southwest China

    Mao Zheng, Ya-Li Wang, N. Zou, et al. · 2026 · Frontiers in Medicine · 3 citations

    Background Vitamin D insufficiency is a global public health concern, particularly among Chinese pregnant women, yet southwest-China data using gold-standard LC-MS/MS are scarce. Methods A retrospective cohort study was conducted on 2,742 pregnancies delivered in Deyang. Serum 25(OH)D2 and 25(OH)D3 quantified by LC-MS/MS (CV < 7%). Univariate and multivariate logistic regression analyses were used to identify risk factors for vitamin D deficiency and assess its associations with pregnancy outcomes. Efficacy of vitamin D supplementation was also compared. Results The median serum 25(OH)D concentration was 16.3 ng/ml, with 62.5% of participants classified as vitamin D deficient (<20 ng/ml). Ea

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  18. Supplementation of vitamin D in children with obesity and vitamin D deficiency - review of outcomes in terms of obesity parameters and comorbidities

    Weronika Kamińska, Adrian Bobrzyk, Grzegorz Łyko, et al. · 2023 · Journal of Education, Health and Sport · 2 citations

    In recent years, vitamin D deficiency and obesity in paediatric population have reached epidemic levels worldwide as crucial health concerns with far-reaching consequences. There has been a substantial growth in studies dedicated to these two public health issues over the last years. Numerous studies have confirmed that excess body weight has negative impact on vitamin D metabolism, leading to a higher risk of low levels of this essential vitamin, among individuals who are overweight or obese. Vitamin D deficiency may play a role in the development of obesity-related conditions as insulin resistance, type two diabetes, NAFLD and cardiovascular disease due to anti-inflammatory properties, imp

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  19. The health outcomes of vitamin D supplementation in Africa: a systematic review and meta-analysis

    Tariku Derese, Yibekal Manaye, Bereket Damtew, et al. · 2025 · BMC Nutrition · 1 citations

    Vitamin D supplementation is essential for health, yet its full benefits and optimal use remain incompletely understood, particularly given the global prevalence of deficiency, which affects around 50% of the population, with higher rates in high-latitude regions and among individuals with darker skin. This systematic review synthesizes evidence on the health outcomes of vitamin D supplementation in Africa, addressing gaps in regional and demographic-specific research. A comprehensive literature search was conducted using PubMed, Scopus, Epistemonikos, and Google Scholar, limited to English-language publications without date restrictions. Two independent reviewers evaluated study eligibility

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  21. Vitamin D Supplementation and Muscle Strength and Bone Health Outcomes: A Phase 3 Randomized Trial in 8,851 Schoolchildren

    G. Davaasambuu · 2022 · Current Developments in Nutrition · 1 citations

    Abstract Objectives To determine the effects of vitamin D supplementation on muscle strength and bone health in vitamin D-deficient schoolchildren. Methods We performed a phase 3 randomized placebo-controlled clinical trial in Ulaanbaatar, Mongolia, to determine whether weekly oral supplementation with 14,000 IU vitamin D3, administered for 3 years in 8,851 schoolchildren aged 6 to 13 years. We evaluated effects of the intervention on bone mineral density (BMD) (n = 1,465), physical fitness (n = 615), long jump (n = 8,850), grip strength (n = 8,850) and incidence of fracture (n = 8,850). Analyses were conducted for all efficacy outcomes to determine whether the effect of the intervention var

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  22. Maternal awareness and practices regarding vitamin D and their impact on health outcomes in children under five years in Egypt

    S. Saleh, Abdelaziz Hendy, R. Ibrahim, et al. · 2026 · Scientific Reports · 1 citations

    Vitamin D is essential for calcium absorption, bone mineralization, and immunological function; nonetheless, vitamin D deficiency (VDD) continues to be a significant health issue in children under five years. In Egypt, VDD is highly prevalent among preschool children, with maternal awareness and nursing practices playing significant roles in its occurrence. This study aimed to identify the relationship between maternal awareness and practices regarding vitamin D and their impact on health outcomes in children under five years. A cross-sectional, correlational, descriptive, and quantitative study was employed. Data collection occurred over eight months throughout three governorates in Egypt,

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  23. Vitamin D supplementation influences the serum lipid profile in the Jordanian population with vitamin D deficiency

    Saad Alfawaeir · 2025 · Nutrición Clínica y Dietética Hospitalaria · 1 citations

    Purpose: To evaluate the association between vitamin D supplementation and changes in lipid profile in a Jordanian population with vitamin D deficiency. Methodology: A total of 95 participants, comprising 35 females aged 15-73 years, were recruited for this prospective investigation and administered vitamin D supplements. Blood specimens were examined for lipid profile characteristics and 25(OH)D3 amounts. Vitamin D supplementation protocole involved the weekly dosing of a single tablet containing 50,000 IU of cholecalciferol for the first four weeks, and bi-weekly medication for the final four weeks. Findings: Before intervention, vitamin D, calcium, total cholesterol, high-density lipoprot

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  24. Impact of Vitamin D supplementation on cognition in adults with mild to moderate vitamin D deficiency: Outcomes from the VitaMIND randomised controlled trial

    A. Corbett, Rod S. Taylor, D. Llewellyn, et al. · 2024 · Alzheimer's & Dementia

    Preserved cognitive health with ageing is a public health imperative. Vitamin D deficiency is associated with poor cognition, but it is unclear whether supplementation would provide benefit, particularly in individuals with mild/moderate deficiencies which do not have other clinical risks. The objective of this study was to establish the impact of daily vitamin D supplementation on cognition in older adults with mild to moderate vitamin D deficiency.

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