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Research papers on Stem cell therapy

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  1. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

    F. Vizoso, N. Eiro, Sandra Cid, et al. · 2017 · International Journal of Molecular Sciences · 1,247 citations

    Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to their capacity for local engrafting and differentiating into multiple tissue types. However, recent studies have revealed that implanted cells do not survive for long, and that the benefits of MSC therapy could be due to the vast array of bioactive factors they produce, which play an important role in the regulation of key biologic processes. Secretome derivatives, such as conditioned media or exosomes, may present considerable advantages over cells for manufacturing, storage, handling, product shelf life and their potential as a ready-to-go biologic product. Nevertheless, regulatory requirements fo

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  2. Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine

    S. Keshtkar, N. Azarpira, M. Ghahremani · 2018 · Stem Cell Research & Therapy · 815 citations

    Mesenchymal stem cells (MSCs) are multipotent stem cells that have gained significant attention in the field of regenerative medicine. The differentiation potential along with paracrine properties of MSCs have made them a key option for tissue repair. The paracrine functions of MSCs are applied through secreting soluble factors and releasing extracellular vesicles like exosomes and microvesicles. Extracellular vesicles are predominantly endosomal in origin and contain a cargo of miRNA, mRNA, and proteins that are transferred from their original cells to target cells. Recently it has emerged that extracellular vesicles alone are responsible for the therapeutic effect of MSCs in plenty of anim

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  3. Potential Strategies to Address the Major Clinical Hurdles Facing Stem Cell Regenerative Therapy for Cardiovascular Disease: A Review

    P. Nguyen, Evgenios A. Neofytou, J. Rhee, et al. · 2016 · JAMA cardiology · 128 citations

    Importance While progress continues to be made in the field of stem cell regenerative medicine for the treatment of cardiovascular disease, significant barriers to clinical translation still exist that have thwarted the delivery of cell therapy to the bedside. Objective The purpose of this review is to summarize the major current hurdles for the clinical implementation of stem cell therapy and discuss potential strategies to overcome them. Evidence Review Information for this review was obtained through a search of PubMed and the Cochrane database for English language studies published between January 1, 2000 and June 15, 2016. Ten randomized clinical trials and eight systematic reviews were

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  4. Therapeutic potential of mesenchymal stem cell-derived exosomes for regenerative medicine applications

    S. Roszkowski · 2024 · Clinical and Experimental Medicine · 120 citations

    Mesenchymal stem cell-derived exosomes have emerged as a promising cell-free therapy for tissue engineering. Compared to intact stem cells, exosomes have advantages like low immunogenicity and ability to carry regenerative cargo. This review examined the potential of exosomes to treat defects in skin, bone and cartilage. In preclinical models, exosomes improved wound healing, stimulated bone regeneration, and enabled cartilage repair by transferring proteins, mRNAs and microRNAs. Their effects were elicited by modulating inflammation, angiogenesis, cell proliferation and matrix synthesis. Exosomes represent a promising cell-free therapy for tissue engineering. However, challenges remain rega

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  5. Revolutionizing medicine: recent developments and future prospects in stem-cell therapy

    B. Hussen, Mohammad Taheri, Raya Kh. Yashooa, et al. · 2024 · International Journal of Surgery (London, England) · 107 citations

    Stem-cell therapy is a revolutionary frontier in modern medicine, offering enormous capacity to transform the treatment landscape of numerous debilitating illnesses and injuries. This review examines the revolutionary frontier of treatments utilizing stem cells, highlighting the distinctive abilities of stem cells to undergo regeneration and specialized cell differentiation into a wide variety of phenotypes. This paper aims to guide researchers, physicians, and stakeholders through the intricate terrain of stem-cell therapy, examining the processes, applications, and challenges inherent in utilizing stem cells across diverse medical disciplines. The historical journey from foundational contr

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  6. Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy

    Vitali V. Maldonado, Neel H. Patel, Emma E. Smith, et al. · 2023 · Journal of Biological Engineering · 104 citations

    Mesenchymal stem/stromal cells (MSCs) have been carefully examined to have tremendous potential in regenerative medicine. With their immunomodulatory and regenerative properties, MSCs have numerous applications within the clinical sector. MSCs have the properties of multilineage differentiation, paracrine signaling, and can be isolated from various tissues, which makes them a key candidate for applications in numerous organ systems. To accentuate the importance of MSC therapy for a range of clinical indications, this review highlights MSC-specific studies on the musculoskeletal, nervous, cardiovascular, and immune systems where most trials are reported. Furthermore, an updated list of the di

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  7. The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles

    M. Jarrige, Elie Frank, Elise Herardot, et al. · 2021 · Cells · 91 citations

    The rapid progress in the field of stem cell research has laid strong foundations for their use in regenerative medicine applications of injured or diseased tissues. Growing evidences indicate that some observed therapeutic outcomes of stem cell-based therapy are due to paracrine effects rather than long-term engraftment and survival of transplanted cells. Given their ability to cross biological barriers and mediate intercellular information transfer of bioactive molecules, extracellular vesicles are being explored as potential cell-free therapeutic agents. In this review, we first discuss the state of the art of regenerative medicine and its current limitations and challenges, with particul

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  8. Prospect of Stem Cell Therapy and Regenerative Medicine in Osteoporosis

    B. Arjmand, Masoumeh Sarvari, Sepideh Alavi-Moghadam, et al. · 2020 · Frontiers in Endocrinology · 76 citations

    The field of cell therapy and regenerative medicine can hold the promise of restoring normal tissues structure and function. Additionally, the main targets of stem cell-based therapies are chronic diseases and lifelong disabilities without definite cures such as osteoporosis. Osteoporosis as one of the important causes of morbidity in older men and post-menopausal women is characterized by reduced bone quantity or skeletal tissue atrophy that leads to an increased risk of osteoporotic fractures. The common therapeutic methods for osteoporosis only can prevent the loss of bone mass and recover the bone partially. Nevertheless, stem cell-based therapy is considered as a new approach to regener

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  9. Advancing Spinal Cord Injury Treatment through Stem Cell Therapy: A Comprehensive Review of Cell Types, Challenges, and Emerging Technologies in Regenerative Medicine

    Chih-Wei Zeng · 2023 · International Journal of Molecular Sciences · 72 citations

    Spinal cord injuries (SCIs) can lead to significant neurological deficits and lifelong disability, with far-reaching physical, psychological, and economic consequences for affected individuals and their families. Current treatments for SCIs are limited in their ability to restore function, and there is a pressing need for innovative therapeutic approaches. Stem cell therapy has emerged as a promising strategy to promote the regeneration and repair of damaged neural tissue following SCIs. This review article comprehensively discusses the potential of different stem cell types, such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), and neura

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  10. Stem Cell and Macrophage Roles in Skeletal Muscle Regenerative Medicine

    P. Scala, L. Rehak, Valentina Giudice, et al. · 2021 · International Journal of Molecular Sciences · 69 citations

    In severe muscle injury, skeletal muscle tissue structure and functionality can be repaired through the involvement of several cell types, such as muscle stem cells, and innate immune responses. However, the exact mechanisms behind muscle tissue regeneration, homeostasis, and plasticity are still under investigation, and the discovery of pathways and cell types involved in muscle repair can open the way for novel therapeutic approaches, such as cell-based therapies involving stem cells and peripheral blood mononucleate cells. Indeed, peripheral cell infusions are a new therapy for muscle healing, likely because autologous peripheral blood infusion at the site of injury might enhance innate i

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  11. Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine

    Yuanting Chen, Huacong Huang, Gaoxing Li, et al. · 2022 · Stem Cell Research & Therapy · 57 citations

    Stem cells transplantation is the main method of tissue engineering regeneration treatment, the viability and therapeutic efficiency are limited. Scaffold materials also play an important role in tissue engineering, whereas there are still many limitations, such as rejection and toxic side effects caused by scaffold materials. Cell sheet engineering is a scaffold-free tissue technology, which avoids the side effects of traditional scaffolds and maximizes the function of stem cells. It is increasingly being used in the field of tissue regenerative medicine. Dental-derived mesenchymal stem cells (DMSCs) are multipotent cells that exist in various dental tissues and can be used in stem cell-bas

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  12. Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review

    Biswajit Panda, Y. Sharma, Suchi Gupta, et al. · 2021 · Life · 53 citations

    Mesenchymal Stem Cells are potent therapeutic candidates in the field of regenerative medicine, owing to their immunomodulatory and differentiation potential. However, several complications come with their translational application like viability, duration, and degree of expansion, long-term storage, and high maintenance cost. Therefore, drawbacks of cell-based therapy can be overcome by a novel therapeutic modality emerging in translational research and application, i.e., exosomes. These small vesicles derived from mesenchymal stem cells are emerging as new avenues in the field of nano-medicine. These nano-vesicles have caught the attention of researchers with their potency as regenerative

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  13. Regenerative medicine in the retina: from stem cells to cell replacement therapy

    Julia Oswald, P. Baranov · 2018 · Therapeutic Advances in Ophthalmology · 51 citations

    Following the fast pace of the growing field of stem cell research, retinal cell replacement is finally emerging as a feasible mean to be explored for clinical application. Although neuroprotective treatments are able to slow the progression of retinal degeneration caused by diseases such as age-related macular degeneration and glaucoma, they are insufficient to fully halt disease progression and unable to recover previously lost vision. Comprehensive, technological and intellectual advances over the past years, including the in vitro differentiation of retinal cells at manufacturing scale from embryonic stem (ES) cell and induced pluripotent stem (iPS) cell cultures, progress within the are

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  14. Enhancing regenerative medicine: the crucial role of stem cell therapy

    Jipeng Wang, Gang Deng, Shu-Yi Wang, et al. · 2024 · Frontiers in Neuroscience · 47 citations

    Stem cells offer new therapeutic avenues for the repair and replacement of damaged tissues and organs owing to their self-renewal and multipotent differentiation capabilities. In this paper, we conduct a systematic review of the characteristics of various types of stem cells and offer insights into their potential applications in both cellular and cell-free therapies. In addition, we provide a comprehensive summary of the technical routes of stem cell therapy and discuss in detail current challenges, including safety issues and differentiation control. Although some issues remain, stem cell therapy demonstrates excellent potential in the field of regenerative medicine and provides novel tact

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  16. Ethical and regulatory issues of stem cell-derived 3-dimensional organoid and tissue therapy for personalised regenerative medicine

    Alexander R. Harris, M. J. Walker, Frederic Gilbert · 2022 · BMC Medicine · 46 citations

    Background Regenerative medicine has the potential to treat genetic disorders and replace damaged or missing tissue. The use of donor or animal tissue raises many well-known issues, including limited tissue availability, the possibility of rejection and patient infection. Stem cell therapy raised hope of overcoming these issues, but created new risks including tumour formation and limited benefit if the desired target tissue does not form. The recent development of 3-dimensional tissues, including organoids, allows the creation of more complex tissues for personalised regenerative medicine. Methods This article details the potential health risks of 3-dimensional organoid and tissue therapy v

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  18. Genetically-Modified Stem Cell in Regenerative Medicine and Cancer Therapy; A New Era.

    A. Hassanzadeh, Somayeh Shamlou, Niloufar Yousefi, et al. · 2021 · Current gene therapy · 32 citations

    Recently, genetic engineering by various strategies to stimulate gene expression in a specific and controllable mode is a speedily growing therapeutic approach. Genetic modification of human stem or progenitor cells, such as embryonic stem cells (ESCs), neural progenitor cells (NPCs), mesenchymal stem/stromal cells (MSCs), and hematopoietic stem cells (HSCs) for direct delivery of specific therapeutic molecules or genes has been evidenced as an opportune plan in the context of regenerative medicine due to their supported viability, proliferative features, and metabolic qualities. On the other hand, a large number of studies have investigated the efficacy of modified stem cells in cancer ther

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  20. Insights on Three Dimensional Organoid Studies for Stem Cell Therapy in Regenerative Medicine

    Precious Earldom Mulaudzi, H. Abrahamse, A. Crous · 2023 · Stem Cell Reviews and Reports · 26 citations

    Regenerative medicine has developed as a promising discipline that utilizes stem cells to address limitations in traditional therapies, using innovative techniques to restore and repair damaged organs and tissues. One such technique is the generation of three-dimensional (3D) organoids in stem cell therapy. Organoids are 3D constructs that resemble specific organs' structural and functional characteristics and are generated from stem cells or tissue-specific progenitor cells. The use of 3D organoids is advantageous in comparison to traditional two-dimensional (2D) cell culture by bridging the gap between in vivo and in vitro research. This review aims to provide an overview of the advancemen

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  21. Regenerative Medicine Therapy in Malaysia: An Update

    S. A. M. Imran, M. Haikal Aiman M. Hamizul, Ahmad Amin Noordin Khairul Bariah, et al. · 2022 · Frontiers in Bioengineering and Biotechnology · 24 citations

    Regenerative medicine is a field in medicine that relates to the ability to correct congenital anomalies and to repair or replace tissues and organs that have been destroyed by age, disease, or trauma. To date, promising preclinical and clinical data supported the possibility of using regenerative medicine to treat both chronic diseases and acute insults, as well as maladies affecting a wide range of organ systems and contexts, such as dermal wounds, cardiovascular diseases and traumas, cancer treatments, and more. One of the regenerative medicine therapies that have been used widely is stem cells. Stem cells, especially mesenchymal and hematopoietic stem cells, play an important role in tre

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  24. Advances in Stem Cell Therapy: A Hope for Regenerative Medicine

    Naveed Shuja · 2024 · DEVELOPMENTAL MEDICO-LIFE-SCIENCES

    Introduction Regenerative medicine has become a light at the end of the tunnel for countless patients who have suffered from diseases previously considered incurable. Stem cell therapy is central to this revolutionary progress and has already made huge advances in recent years. Stem cells have the potential to regenerate tissues, repair organs, and even modulate immune responses, making them a key to delivering innovative treatments for a broad spectrum of medical conditions. This editorial describes recent progress in stem cell therapy as well as its promise as a regenerative medicine[1]. Stem Cells have unique Properties. Stem cells have unique properties that make them of great value in t

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