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Research papers on Epigenetics and disease

Recent and highly-cited academic work on epigenetics and disease, gathered from Semantic Scholar, CrossRef and OpenAlex.

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  6. From Environment to Gene Expression: Epigenetics and the Development of Mental Health Disorders

    Jennings Hernandez · 2023 · International Neuropsychiatric Disease Journal · 2 citations

    Psychiatric disorders have multifaceted origins, involving a combination of genetic and environmental factors that contribute significantly to their development. In recent times, researchers have emphasized the role of epigenetic mechanisms as the underlying molecular foundation for how environmental factors influence biological processes. Consequently, the field of epigenetics has gained growing prominence within the realm of psychiatry as a means to understand these intricate connections. This qualitative research paper explores the role of epigenetics in mental health disorders, focusing on the impact of environmental factors on gene expression. By examining the complex interplay between

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  8. Epigenetics: The Impact of Trauma on Gene Expression and Transgenerational Transmission

    Sama A. Akbarli, Chilanay M. Alakbarova · 2026 · Journal of Molecular Biosciences and Engineering

    This study examines the relationship between childhood trauma and epigenetic changes in genes that regulate the stress response. Traumas such as violence or lack of control experienced at an early age can disrupt the long-term regulatory mechanisms of the hypothalamic-pituitary-adrenal (HPA) axis, leading to impaired stress responses. Epigenetic mechanisms such as DNA methylation, histone modifications, and non-coding RNAs play an important role in the stress response by regulating gene expression without altering the DNA sequence. Genes such as FKBP5, MAOA, and NR3C1, which are important in stress regulation, are sensitive to childhood trauma; changes in their methylation and transcription

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  9. Epigenetics and Dietary Phytochemicals: Modulating Gene Expression for Disease Prevention

    T. Divya, A. Mangala Gowri · 2026 · Journal of Advances in Biology & Biotechnology

    Epigenetics refers to changes in chromatin organisation and gene expression that occur without alteration of the DNA sequence. This review discusses how dietary phytochemicals and nutritional states may influence epigenetic mechanisms relevant to disease prevention. The manuscript focuses on DNA methylation, histone acetylation, histone methylation, histone biotinylation and microRNA-mediated regulation, and describes how these processes can be affected by nutrients, methyl donors and bioactive plant compounds. Evidence discussed in the review indicates that nutrition during maternal, paternal, periconceptional and postnatal periods can influence methylation patterns, gene expression and met

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  11. The Influence of Epigenetics on Gene Expression: Mechanisms, Environmental Interactions and Clinical Applications in Disease Prevention and Treatment

    Yun Ao · 2025 · Theoretical and Natural Science

    Epigenetics, as defined, is a crucial field of heritable modifications in gene activity or function independent of genetic DNA code variability. Determining this knowledge is very important. The review will elaborate on the principal epigenetic mechanisms comprising DNA methylation, histone modifications, and non-coding RNAs. Each bears responsibilities for being a major contributor to specifying gene expression as well as guardians for maintaining genomic stability. It also covers the impact of environmental factors, including nutrition, psychosocial stress, and toxic exposure, on changing epigenetic states often associated with shifts in disease susceptibility. By focusing on paradigmatic

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